Proteomics Department

The Department of Proteomics focuses on the properties and functions of cellular proteins in connection with the origin, development and treatment of hematological diseases.

Our goal is to understand the specific molecular mechanisms involved in the regulation of normal and pathological hematopoiesis or in the effect of established and experimental therapeutic procedures. To this end, we use basic techniques of cell and molecular biology (flow cytometry, western blot, immunofluorescence microscopy, molecular cloning) in combination with other methods and procedures that allow a comprehensive view of cellular protein behavior.

In addition to solving basic and applied research projects, we also collaborate in the introduction of new diagnostic methods for hematology.

• As part of the independent antibody validation initiative on antibodies-online, we validated an antibody against nucleophosmin. See the results.

List of topics currently being addressed in the Department of Proteomics:

• Analysis of the mechanism of drug action on proteins associated with apoptosis
• Significance of C-terminal mutations of nucleophosmin in acute myeloid leukemia
• Mechanisms of escape from immune surveillance in acute myeloid leukemia
• Exosomes CML, proteomics and surface markers
• Search for intervention sites in cells of chronic myeloid leukemia resistant to standard therapy
• Interaction of hematopoietic cells with extracellular matrix proteins
• Regulation of adhesion interactions in B-ALL immunotherapy