List of Active Studies

EU Trial Number	Protocol Number	Diagnoses	Study Description	Principal Investigator	Coordinator	Recruitment
PHASE 1
Eudra CT 2024-510815-30-00	UHKT-CAR19-01, NCT05054257	B-ALL, B-NHL	Clinical evaluation of the safety and efficacy of autologous CART19 lymphocytes in patients with relapsed or refractory acute B-lymphoblastic leukemia (B-ALL) or relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL). Open Phase I study with dose escalation.	MUDr. Jan Vydra, Ph.D. jan.vydra@uhkt.cz	Mgr. Tereza Brabencová Tereza.Brabencova@uhkt.cz Kateřina Waldmannová Katerina.Waldmannova@uhkt.cz	yes
EU CT 2022-503165-30-00	UHKT-CAR123-01, NCT06765876	CD123+/ AML, ALL, MDS-IB2, BPDCN	Safety and efficacy of autologous CART123 lymphocytes in patients with relapsed or refractory CD123 positive hematologic malignancy. Open Phase I study with dose escalation.	MUDr. Jan Vydra, Ph.D. jan.vydra@uhkt.cz	Mgr. Tereza Brabencová Tereza.Brabencova@uhkt.cz Kateřina Waldmannová Katerina.Waldmannova@uhkt.cz	yes
EU CT 2024-517681-41	IM060-0001	SLE, SSc, IIM, RA	Phase 1, multicenter, open-label study of BMS-986515, from healthy donors allogeneic CD19-targeted chimeric antigen receptor (CAR) T cells, in participants with severe, refractory autoimmune diseases Study in cooperation with the Institute of Rheumatology as a referring center.	MUDr. Ladislav Šenolt, Ph.D. (IR) MUDr. Jan Vydra, Ph.D. (ÚHKT) jan.vydra@uhkt.cz	Ing. Anna Dobrovolná Anna.Dobrovolna@uhkt.cz Bc. Michaela Kosternová Michaela.Kosternova@uhkt.cz	yes
PHASE 1/2
EU CT 2024-515034-33	AZDO486 — D7407C00001	CLL	Open multicenter Phase I/II master protocol to evaluate the safety and efficacy of AZD0486 as monotherapy or in combination with other anticancer agents in participants with mature B-cell malignancies.	MUDr. Robert Pytlík, Ph.D. Robert.Pytlik@uhkt.cz	Bc. Michaela Kosternová Michaela.Kosternova@uhkt.cz	yes
	UHKT-PTC-TMI-01	AML, MDS	Proton radiotherapy of bone marrow (Total Marrow Irradiation) as part of preparatory regimen prior to allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome. Phase I/II pilot study.	doc. 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