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Science and research

Grant Projects (ongoing in the year 2011)

View ongoing grants in the year: 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024.

Quality of life measurement and its influence to overall survival in hematopoietic stem cell transplantation in CZ

IGA MZd NT 11299 [2010 – 2015]

prof. MUDr. Marek Trněný, CSc.
MUDr. Veronika Válková, CSc.

The co-recipient from the transplant center of Institute of Hematology and Blood Transfusion is responsible for anonymous data of patients after autologous and allogeneic hematopoietic stem cells transplant to the database of EBMT (The European Group for Blood and Marrow Transplantation). This data will be used for characterization of the particular diagnostic groups within the project frame. The main aim of the presenting grant project is to analyze the quality of life (QOL) of the transplanted patients using standardized QOL surveys. The co-recipient´s team consists from a physician and datamanager, who will be responsible for the data collecting using the QOL surveys and their subsequent processing to the Principal investigators team. The main benefit is an expansion of the co-investigators view to the psycho-social perspective of the patients.

Development of a Novel Recombinogenic Technique for Chloroplast Transformation and its Use for Production of human papillomavirus E7 Protein in Plants

IAA500960903 [2009 – 2012]

Doc. RNDr. Josef Vlasák, CSc., Biologické centrum AV ČR, v.v.i.
RNDr. Viera Ludvíková

Our aim is to develop more efficient method for plant chloroplast transformation using biolistic bombardment with linear DNA vectors together with chloroplast cassettes expressing bacteriophage lambda Red proteins. The idea stems from experiments with targeted insertion mutagenesis in yeast, cyanobacteria, and E. coli, where DNA ends promote recombination, and lambda Red proteins Exo, Beta, and Gam are very efficient in short recombinogenic ends protection and processing. Linear vectors can be generated conveniently as PCR products with synthetic primer ends that are homologous to sequence targets in the chloroplast genome. Chloroplast vectors will carry marker genes and also human papillomavirus oncogene E7 in the form of highly immunogenic but nononcogenic fusion E7GGG/GUS. It is our goal to obtain transplastomic plants producing this antigen with potential use as therapeutic vaccine. Viral antigens produced in plants will be assayed with antibodies and tested in mice.

Development of a Novel Recombinogenic Technique for Chloroplast Transformation and its Use for Production of human papillomavirus E7 Protein in Plants

COST Action BM0801 [2010 – 2012]

haskovec

Molecular analysis of epigenetic changes in AML and MDS patients for prognosis, progression and monitoring of treatment of the patients. Comparison of methylation in promotor parts of selected genes at diagnosis and during treatment of AML and MDS patients. Methods: DNA methylation arrays, bisulfite sequencing, methylation-specific PCR in real-time.

Effect of vaccination in patients with recurrent respirátory papillomatosis – can we improve the quality of life of these patients?

Merc & Dohme s.r.o. IIS ID 37651 [2011 – 2016]

RNDr. Ruth Tachezy, Ph.D.
MUDr. Jitka Vydrová – Medical Healthcom., s.r.o., Hlasové centrum, Praha

Phase III b clinical study. The main objective of the study will be to evaluate the impact of the tetravalent HPV vaccine on the occurrence of recurrent papillomatous lesions and remission duration in patients with recurrent respiratory papillomatosis (RRP). Secondary objectives will be to determine the HPV type involved in a RRP lesion and to monitor the levels of antibodies against the vaccine antigens or immune system components in the blood serum.

Origin of childhood leukaemias

IGA MZd NT 12328-5 [2011 – 2015]

doc. MUDr. Jan Zuna, Ph.D., 2. LF UK Praha
MUDr. Ivan Fales

Dr Ivan Fales and Dr Šárka Rahmatová are working in the Cord Blood Bank Czech Republic (CBB) as medical doctors and coordinators. They are responsible for related and unrelated part of CBB, for selection of mother-donors, for processing, cryopreservation and long-term storage of the cord blood grafts. Further more, they are responsible for the control of the processed grafts and for submission of the completely tested grafts to the Czech Stem Cells Registry (CSCR). The cord blood grafts are offered through CSCR for searches and transplantations. CBB Czech Republic closely cooperates with CSCR on selection and shipment of cord blood grafts for transplantation and also for elimination of the grafts in case of the child's (donor's) illness. In this project CBB will be responsible for the collection of cord blood samples of donors (mothers) with signed informed consent and for elimination of the cord blood grafts from the CSCR including the cases of haematological malignancy of the donor child. In these cases the cord blood samples and the grafts will be handed over to the CLIP laboratories for research purposes.


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Head of Science and Research Division
Tel:+420 221 977 208

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Tel:+420 221 977 269
Tel:+420 221 977 364

Secretary
Tel:+420 221 977 247


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Ústav hematologie a krevní transfuze
(​Institute of Hematology and Blood Transfusion)

U Nemocnice 2094/1
128 00 Praha 2

The nearest underground station: Karlovo náměstí (line B)

The nearest tram station: Karlovo náměstí (10, 16, 22), Moráň (3, 6, 10, 16, 18, 24)

The nearest bus station: U Nemocnice (148), Karlovo náměstí (176)

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