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Science and research

Laboratory of Immunotherapy and Gene Therapy of Tumors

For a long time the main focus of the group has been the preclinical research of active and passive immunotherapy that could be applied to the treatment of patients with leukemia.

Recently the group has completed the clinical study of the immunological profile of patients at the time of diagnosis of chronic myeloid leukemia (CML) and during therapy with ABL kinase inhibitors. In the blood of patients at diagnosis an increase of several factors responsible for immune response escape such as IDO, arginase I, soluble CD25 and MDSC population was observed. Several-fold increased levels of 20 cytokines found at diagnosis dropped significantly at the time of remission. These results suggest that increased levels of IL-8, IL-5 and MCP-1 at the time of diagnosis could have the role of a positive prognostic marker.

For a longer time the group has been engaged in the development of vaccines against CML using the mouse model. Currently, the experimental cellular vaccines modified by insertion of immunostimulatory molecules for therapy of minimal residual disease in patients with CML are being prepared and examined in vitro. The vaccine immunogenicity will be enhanced by blocking the immune escape mechanisms of the tumor. The vaccines are assigned for adjuvant therapy to the primary treatment of chronic/acute myeloid leukemias.


Quick contact

Head of Science and Research Section
Tel:+420 221 977 208

Deputy head of Science and Research Section
Tel:+420 221 977 269
Tel:+420 221 977 364

Secretary
Tel:+420 221 977 247


Opening hours

Ambulance
Mo – Fr: 7:00–18:00
Weekends: 9:00–13:00

Donors
Mo – Fr: 7:00–10:30

Visitors
Inpatient department
Mo – Fr: 13:00–18:00

ICU and Transplant unit
Mo – Fr: 14:00–17:00

How to find us

map

Ústav hematologie a krevní transfuze
(​Institute of Hematology and Blood Transfusion)

U Nemocnice 2094/1
128 20 Praha 2

The nearest underground station: Karlovo náměstí (line B)

The nearest tram station: Karlovo náměstí (10, 16, 22), Moráň (3, 6, 10, 16, 18, 24)

The nearest bus station: U nemocnice (291), Karlovo náměstí (176)

How to get here