Research Division

The main research areas of IHBT

• Chronic myeloid leukemia
• Myelodysplastic syndrome
• Acute myeloid leukemia
• Development of new methods of cell and gene therapy of hematological malignancies
• Thrombosis and Hemostasis
• Hemophilia, von Willebrand disease, and rare disorders of hemostasis
• Other rare blood diseases
• Iron metabolism
• Hematopoietic cell transplantation
• Areas of applied research and technology transfer

The main research topics

• Monitoring genome and gene expression in onco-hematological diseases
• Studying protein expression (proteome) and protein interactions (interactome and complexome) in leukemic cells and their changes related to malignancies
• Studying the pathogenesis of myelodysplastic syndrome (MDS)
• Studying the pathogenesis of chronic myeloid leukemia (CML) and its resistance to its treatment
• Looking for targeted therapies for CML cells resistant to common therapy
• Congenital diseases of hematopoiesis
• Studying methylation and acetylation as epigenetic mechanisms that complement each other and regulate gene and protein expression in cells
• Biosensors with surface plasmons and protein microarrays for medical diagnostics
• Proteome analysis of the effects of administered pharmacological drugs (imatinib mesylate, dasatinib, saracatinib, SAHA – suberoylanilide hydroxamic acid) on human blood cells
• The role of cytokines in the development of graft-versus-host disease (GVHD) after the allogeneic transplantation of hemopoietic stem cells
• Research into DNA tumor viruses
• Developing immunotherapeutic strategies and vaccines for CML and AML on mouse models
• Studying adhesion structures and signalling pathways controlling cell adhesion to the extracellular matrix and cell migration of blood cells
• Studying iron absorption and metabolism in the human body
• Epidemiological studies based on molecular-biological and serological markers of papillomavirus and polyomavirus infections related to human malignancies

The Research Division consists of seven departments:

• Department of Biochemistry
• Department of Cytogenetics
• Department of Genomics
• Department of HLA
• Department of Molecular Genetics
• Department of Proteomics