Science and research

Research Division

The main research areas of IHBT

  • Chronic myeloid leukemia
  • Myelodysplastic syndrome
  • Acute myeloid leukemia
  • Development of new methods of cell and gene therapy of hematological malignancies
  • Thrombosis and Hemostasis
  • Hemophilia, von Willebrand disease, and rare disorders of hemostasis
  • Other rare blood diseases
  • Iron metabolism
  • Hematopoietic cell transplantation
  • Areas of applied research and technology transfer

The main research topics

  • Monitoring genome and gene expression in onco-hematological diseases
  • Studying protein expression (proteome) and protein interactions (interactome and complexome) in leukemic cells and their changes related to malignancies
  • Studying the pathogenesis of myelodysplastic syndrome (MDS)
  • Studying the pathogenesis of chronic myeloid leukemia (CML) and its resistance to its treatment
  • Looking for targeted therapies for CML cells resistant to common therapy
  • Congenital diseases of hematopoiesis
  • Studying methylation and acetylation as epigenetic mechanisms that complement each other and regulate gene and protein expression in cells
  • Biosensors with surface plasmons and protein microarrays for medical diagnostics
  • Proteome analysis of the effects of administered pharmacological drugs (imatinib mesylate, dasatinib, saracatinib, SAHA – suberoylanilide hydroxamic acid) on human blood cells
  • The role of cytokines in the development of graft-versus-host disease (GVHD) after the allogeneic transplantation of hemopoietic stem cells
  • Research into DNA tumor viruses
  • Developing immunotherapeutic strategies and vaccines for CML and AML on mouse models
  • Studying adhesion structures and signalling pathways controlling cell adhesion to the extracellular matrix and cell migration of blood cells
  • Studying iron absorption and metabolism in the human body
  • Epidemiological studies based on molecular-biological and serological markers of papillomavirus and polyomavirus infections related to human malignancies

The Research Division consists of seven departments:

Quick contact

Head of Science and Research Division
Tel:+420 221 977 305

Deputy head of Science and Research Division
Tel:+420 221 977 648

Tel:+420 221 977 144

Opening hours

Mo – Fr: 7:00–18:00
Weekends: 9:00–13:00

Mo – Fr: 7:00–10:30

Inpatient department
Mo – Fr: 13:00–18:00

ICU and Transplant unit
Mo – Fr: 14:00–17:00

How to find us


Ústav hematologie a krevní transfuze
(​Institute of Hematology and Blood Transfusion)

U Nemocnice 2094/1
128 00 Praha 2

The nearest underground station: Karlovo náměstí (line B)

The nearest tram station: Karlovo náměstí (10, 16, 22), Moráň (3, 6, 10, 16, 18, 24)

The nearest bus station: U Nemocnice (148), Karlovo náměstí (176)

How to get here