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Science and research

The role of C-Terminal Nucleophosmin Mutations in AML

Specific C-terminal mutations in the gene for nucleophosmin 1 (NPM1) are found in about 30% of patients with acute myelogenous leukemia and are associated with better prognosis. The mutations are known to induce changes in the protein intracellular localization which presumably lead to a partial loss of function.

However, the role of the mutated NPM in leukemogenesis is still unknown. We focus on detailed characterization of changes in NPM localization, oligomerization and protein-protein complex formation due to different C-terminal mutations that are found in AML patients.


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Ústav hematologie a krevní transfuze
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U Nemocnice 2094/1
128 20 Praha 2

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