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Experimental Virology Department

Administrative and personal data about the department.

Department of Experimental Virology – the main topic is to contribute to the elucidation of role of virus infections in human cancer pathogenesis and to search tools to solution of these compelling public health problems. Methods used are molecular biological and immunological evidence of virus infections, molecular– and seroepidemiological studies, gene therapy of tumors, and development of new generation vaccines based on DNA, recombinant viruses or dendritic cells.

In situ hybridization - detection of papillomaviruses inside a cell.

The central role in the research domain play human papillomaviruses (HPV) causally linked to the development of cervical cancer and possibly also to at least a part of other human malignancies. Experimental studies are performed on animal models, where the HPV–induced tumors serve as targets for gene therapy and prophylactic or therapeutic vaccination.

The important part of the Department of Experimental Virology is the National Referency Laboratory for HPV. The department comprises of several groups: laboratory of recombinant vaccines, laboratory of molecular oncology, laboratory of viral molecular epidemiology, laboratory of immunotherapy and gene therapy, and National Referency Laboratory for Papillomaviruses.

Output of a sequential analysis of papillomavirus typing.