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    • Dpt. of Cell Biochemistry
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    • Dpt. of Experimental Virology
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Cell Biochemistry Department

Administrative and personal data about the department.

Department of Cellular Biochemistry is interested in the studies of blood cells structure, investigations of serious defects of their vital processes and in examinations of medical corrections of pathology caused by intracellular defects. The research aims to reveal origins and reasons of development of hematooncological malignancies in intention for application of new findings in diseases prevention, diagnostics and therapy. Noxious side effects of cytostatic and cytotoxic drugs on blood cells homeostasis and methods of their minimalization are also investigated. Most modern methods of biological and biochemical research are used, including methods of proteom analysis and protein immunodetection, real time PCR and other methods of molecular biology and the immunofluorescence imaging of cellular proteins and structures.

Two-dimensional protein map of the cell line K562 derived from the chronic myelogenous leukemia. The map was obtained by combining electrophoretic separation of cellular proteins according to their isoelectric point (x-coordinate) and molecular mass (y-coordinate). The proteins depicted were identified using mass spectrometry by determining the molecular mass of peptides resulting from the tryptic digestion of proteins in situ (MALDI-TOF) or their partial aminoacid sequence (MALDI-MS/MS)