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Immunohematology Department

Administrative and personal data on the department.

Immunohematology Department consist of three parts – laboratories for red cell immunohematology, laboratory for immunohematology of platelets and leukocytes and HLA laboratory. Red cell immunohematology laboratories are divided in two parts – routine and specialized lab. Routine laboratory perform obligatory testing of blood donors oth the Transfusion and Apheresis Departments (AB0 RhD typing, Rh-Kell phenotyping, antibody screening and titration) and pretransfusion compatibility testing for patients of the Clinical Department.

Specialized laboratory (recognized by MZd ČR as Reference Laboratory for Immunohematology) is performing specialized test in complicated cases as a service for blood transfusion laboratories in the Czech (and Slovak) Republic, especially identification of allo- and autoantibodies, problem solving in blood grouping discrepancies (rare, weak and variant antigens, etc).

Laboratory for platelets and leukocyte immunohematology is testing platelets and leukocytes antigens and corresponding antibodies.

HLA laboratory is performing HLA typing of patients of the Clinical Department and providing this service for other clinics of the Faculty Hospital and is involved in the blood donor HLA typing and in the process of donor selection for the bone marrow transplantation.

DI is performing clasical serologic immunohematology methods (tube tests, column agglutination tests, lymphocytotoxic test, immunofluorescencetests, ELISA, MAIPA) and also DNA typing (blood group genotyping PCR-SSP, HPA PCR-SSP, HLA PCR-SSP).DI is participating on the EU Project BloodGen (blood group genotyping microarrays) with the aim to evaluate automated mass genotyping technology and introduce new diagnostic device – BloodChip (microarray for simultaneous genotyping of cca 100 clinically important blood group polymorphisms).