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Science and research

Effects of Epigenetic Drugs on Nucleolar and Apoptosis-Related Proteins

The current standard treatment protocols for acute myeloid leukemia (AML) involving essentially high-dose chemotherapy do not produce satisfactory results for all AML subtypes, especially for high-risk AML. New approaches involve, for example, the use of epigenetic drugs which affect the methylation and acetylation profile of both nucleic acids and proteins.

We explore the effect of the established drugs (such as cytarabin, all-trans retinoic acid or actinomycin D) and epigenetic modulators (such as decitabine or inhibitors of histone deacetylases) in order to find the best combination to maximize the toxic effects on leukemic cells while sparing the normal cells. As the main goal of the therapy is to induce the apoptosis in leukemic cells, we particularly focus on the proteins regulating this process – e.g. the tumor suppressor p53, Bcl-2 family of proteins and the IAP group.


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Ústav hematologie a krevní transfuze
(​Institute of Hematology and Blood Transfusion)

U Nemocnice 2094/1
128 20 Praha 2

The nearest underground station: Karlovo náměstí (line B)

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