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Science and research

Laboratory of Recombinant Vaccines

The main interest lies in the development of protocols for ex vivo expansion of multi-specific T cell lines that could be used for the prevention of severe viral infections in immunosuppressed patients or as a substrate for the preparation of genetically modified T cell lines. T cells are stimulated with various forms of antigen such as dendritic cells electroporated with synthetic in vitro transcribed mRNA coding for viral proteins or mixtures of overlapping synthetic peptides derived from viral antigens and by cultivation in the presence of cytokines. In parallel, chimeric antibody receptors (CARs) with specificity for virus encoded antigens or leukemia associated antigens for genetic modification of T cells are prepared in co-operation with the immunotherapeutic group.

Recently, we have introduced an assay for the detection of antigen specific cellular immunity against human cytomegalovirus (HCMV). Evaluation of this ELISPOT-interferon gamma test performed in a prospective study with 27 recipients of hematopoietic stem cells has revealed the suitability of the assay for the search for patients who are at high risk of reactivation of HCMV infection.


Quick contact

Head of Science and Research Division
Tel:+420 221 977 208

Deputy head of Science and Research Division
Tel:+420 221 977 269
Tel:+420 221 977 364

Secretary
Tel:+420 221 977 247


Opening hours

Ambulance
Mo – Fr: 7:00–18:00
Weekends: 9:00–13:00

Donors
Mo – Fr: 7:00–10:30

Visitors
Inpatient department
Mo – Fr: 13:00–18:00

ICU and Transplant unit
Mo – Fr: 14:00–17:00

How to find us

map

Ústav hematologie a krevní transfuze
(​Institute of Hematology and Blood Transfusion)

U Nemocnice 2094/1
128 20 Praha 2

The nearest underground station: Karlovo náměstí (line B)

The nearest tram station: Karlovo náměstí (10, 16, 22), Moráň (3, 6, 10, 16, 18, 24)

The nearest bus station: U nemocnice (291), Karlovo náměstí (176)

How to get here